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[[Image:1kwk.png|left|200px]]


{{STRUCTURE_1kwk|  PDB=1kwk  |  SCENE=  }}
==Crystal structure of Thermus thermophilus A4 beta-galactosidase in complex with galactose==
 
<StructureSection load='1kwk' size='340' side='right'caption='[[1kwk]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
===Crystal structure of Thermus thermophilus A4 beta-galactosidase in complex with galactose===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1kwk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KWK FirstGlance]. <br>
{{ABSTRACT_PUBMED_12215416}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kwk OCA], [https://pdbe.org/1kwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kwk RCSB], [https://www.ebi.ac.uk/pdbsum/1kwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kwk ProSAT]</span></td></tr>
[[1kwk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWK OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/BGAL_THETH BGAL_THETH]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/1kwk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kwk ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Galactosidase|Galactosidase]]
*[[Galactosidase 3D structures|Galactosidase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:012215416</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Beta-galactosidase]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Fushinobu, S.]]
[[Category: Fushinobu S]]
[[Category: Hidaka, M.]]
[[Category: Hidaka M]]
[[Category: Matsuzawa, H.]]
[[Category: Matsuzawa H]]
[[Category: Motoshima, H.]]
[[Category: Motoshima H]]
[[Category: Ohtsu, N.]]
[[Category: Ohtsu N]]
[[Category: Shoun, H.]]
[[Category: Shoun H]]
[[Category: Wakagi, T.]]
[[Category: Wakagi T]]
[[Category: Galactose complex]]
[[Category: Glycoside hydrolase family 42]]
[[Category: Hydrolase]]
[[Category: Tim barrel]]
[[Category: Trimer]]

Latest revision as of 13:26, 13 March 2024

Crystal structure of Thermus thermophilus A4 beta-galactosidase in complex with galactose

1kwk, resolution 2.20Å

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