3dab: Difference between revisions

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[[Image:3dab.png|left|200px]]


{{STRUCTURE_3dab| PDB=3dab | SCENE= }}
==Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain==
<StructureSection load='3dab' size='340' side='right'caption='[[3dab]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3dab]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dab OCA], [https://pdbe.org/3dab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dab RCSB], [https://www.ebi.ac.uk/pdbsum/3dab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dab ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dab_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dab ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction.


===Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain===
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.,Popowicz GM, Czarna A, Holak TA Cell Cycle. 2008 Aug;7(15):2441-3. Epub 2008 May 27. PMID:18677113<ref>PMID:18677113</ref>


{{ABSTRACT_PUBMED_18677113}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3dab" style="background-color:#fffaf0;"></div>
[[3dab]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAB OCA].


==See Also==
==See Also==
*[[MDM4|MDM4]]
*[[MDM4|MDM4]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:018677113</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Czarna, A.]]
[[Category: Large Structures]]
[[Category: Holak, T A.]]
[[Category: Czarna A]]
[[Category: Popowicz, G M.]]
[[Category: Holak TA]]
[[Category: Apoptosis]]
[[Category: Popowicz GM]]
[[Category: Cell cycle]]
[[Category: Disease mutation]]
[[Category: Dna-binding]]
[[Category: Hdm2]]
[[Category: Hdm4]]
[[Category: Hdmx]]
[[Category: Mdm-4]]
[[Category: Mdm-x]]
[[Category: Mdm2]]
[[Category: Mdm4]]
[[Category: Mdmx]]
[[Category: Nucleus]]
[[Category: Oncogene]]
[[Category: P53]]
[[Category: Transcription]]
[[Category: Tumor]]
Retrieved from "https://proteopedia.org/3dab"