2b35: Difference between revisions
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==Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan== | |||
<StructureSection load='2b35' size='340' side='right'caption='[[2b35]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2b35]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B35 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b35 OCA], [https://pdbe.org/2b35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b35 RCSB], [https://www.ebi.ac.uk/pdbsum/2b35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b35 ProSAT]</span></td></tr> | ||
[[2b35]] is a 6 chain structure with sequence from [ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b35_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b35 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Enoyl-Acyl-Carrier Protein Reductase|Enoyl-Acyl-Carrier Protein Reductase]] | *[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
< | [[Category: Large Structures]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Amin | [[Category: Amin A]] | ||
[[Category: Boyne | [[Category: Boyne MS]] | ||
[[Category: Johnson | [[Category: Johnson F]] | ||
[[Category: Kaur | [[Category: Kaur T]] | ||
[[Category: Novichenok | [[Category: Novichenok P]] | ||
[[Category: Stratton | [[Category: Stratton C]] | ||
[[Category: Sullivan | [[Category: Sullivan TJ]] | ||
[[Category: Truglio | [[Category: Truglio JJ]] | ||
[[Category: Zhang | [[Category: Zhang X]] | ||
Latest revision as of 09:15, 14 February 2024
Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan
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