3ovm: Difference between revisions
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==X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values== | |||
<StructureSection load='3ovm' size='340' side='right'caption='[[3ovm]], [[Resolution|resolution]] 2.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3ovm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OVM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MZC:METHYL+{3-[2-(ACETYLAMINO)ETHYL]-1H-INDOL-5-YL}CARBAMATE'>MZC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ovm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ovm OCA], [https://pdbe.org/3ovm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ovm RCSB], [https://www.ebi.ac.uk/pdbsum/3ovm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ovm ProSAT]</span></td></tr> | ||
[[3ovm]] is a 2 chain structure with sequence from [ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | |||
==See Also== | ==See Also== | ||
*[[Quinone reductase|Quinone reductase]] | *[[Quinone reductase 3D structures|Quinone reductase 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Boutin | [[Category: Large Structures]] | ||
[[Category: Delagrange | [[Category: Boutin JA]] | ||
[[Category: Ferry | [[Category: Delagrange P]] | ||
[[Category: Pegan | [[Category: Ferry G]] | ||
[[Category: Sturdy | [[Category: Pegan SD]] | ||
[[Category: Sturdy M]] | |||
Latest revision as of 10:36, 21 February 2024
X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values
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