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[[Image:3sxe.png|left|200px]]


{{STRUCTURE_3sxe|  PDB=3sxe  |  SCENE=  }}
==Crystal structure of AAAA+UDP+Gal with Glycerol as the cryoprotectant==
 
<StructureSection load='3sxe' size='340' side='right'caption='[[3sxe]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
===Crystal structure of AAAA+UDP+Gal with Glycerol as the cryoprotectant===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3sxe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The December 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''ABO Blood Type Glycosyltransferases''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_12 10.2210/rcsb_pdb/mom_2012_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SXE FirstGlance]. <br>
{{ABSTRACT_PUBMED_22349229}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sxe OCA], [https://pdbe.org/3sxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sxe RCSB], [https://www.ebi.ac.uk/pdbsum/3sxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sxe ProSAT]</span></td></tr>
[[3sxe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXE OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.


==See Also==
==See Also==
*[[Galactosyltransferase|Galactosyltransferase]]
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:022349229</ref><references group="xtra"/>
[[Category: ABO Blood Type Glycosyltransferases]]
[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Evans, S V.]]
[[Category: Large Structures]]
[[Category: Johal, A R.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Abo rossmann fold]]
[[Category: Evans SV]]
[[Category: Blood group antigen]]
[[Category: Johal AR]]
[[Category: Glycoprotein]]
[[Category: Manganese]]
[[Category: Metal-binding]]
[[Category: Retaining glycosyltransferase]]
[[Category: Transferase]]
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