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[[Image:1ma0.png|left|200px]]


{{STRUCTURE_1ma0|  PDB=1ma0  |  SCENE=  }}
==Ternary complex of Human glutathione-dependent formaldehyde dehydrogenase with NAD+ and dodecanoic acid==
 
<StructureSection load='1ma0' size='340' side='right'caption='[[1ma0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Ternary complex of Human glutathione-dependent formaldehyde dehydrogenase with NAD+ and dodecanoic acid===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ma0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MA0 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12196016}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ma0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ma0 OCA], [https://pdbe.org/1ma0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ma0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ma0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ma0 ProSAT]</span></td></tr>
[[1ma0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MA0 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ADHX_HUMAN ADHX_HUMAN] Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ma/1ma0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ma0 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Alcohol dehydrogenase|Alcohol dehydrogenase]]
*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:012196016</ref><references group="xtra"/>
[[Category: Alcohol dehydrogenase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bosron, W F.]]
[[Category: Large Structures]]
[[Category: Hurley, T D.]]
[[Category: Bosron WF]]
[[Category: Robinson, H.]]
[[Category: Hurley TD]]
[[Category: Sanghani, P C.]]
[[Category: Robinson H]]
[[Category: Class iii alcohol dehydrogenase]]
[[Category: Sanghani PC]]
[[Category: Human glutathione-dependent formaldehyde dehydrogenase]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/1ma0"