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[[Image:2ytc.png|left|200px]]


{{STRUCTURE_2ytc|  PDB=2ytc  |  SCENE=  }}
==Solution structure of RNA binding domain in Pre-mRNA-splicing factor RBM22==
 
<StructureSection load='2ytc' size='340' side='right'caption='[[2ytc]]' scene=''>
===Solution structure of RNA binding domain in Pre-mRNA-splicing factor RBM22===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2ytc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YTC FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ytc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ytc OCA], [https://pdbe.org/2ytc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ytc RCSB], [https://www.ebi.ac.uk/pdbsum/2ytc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ytc ProSAT], [https://www.topsan.org/Proteins/RSGI/2ytc TOPSAN]</span></td></tr>
[[2ytc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YTC OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/RBM22_HUMAN RBM22_HUMAN] Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.<ref>PMID:17045351</ref> <ref>PMID:21122810</ref> <ref>PMID:22246180</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yt/2ytc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ytc ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Inoue, M.]]
[[Category: Large Structures]]
[[Category: Kasahara, N.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kasahara N]]
[[Category: Muto, Y.]]
[[Category: Kigawa T]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Muto Y]]
[[Category: Shirouzu, M.]]
[[Category: Shirouzu M]]
[[Category: Terada, T.]]
[[Category: Terada T]]
[[Category: Tsuda, K.]]
[[Category: Tsuda K]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rbd]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rrm domain]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/2ytc"