5zna: Difference between revisions

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[[~~Image~~:5zna.~~png|~~left~~|200px~~]]

==EVIDENCE FOR A NEW Z-TYPE LEFT-HANDED DNA HELIX: PROPERTIES OF Z(WC)-DNA==

== Structural highlights ==

<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZNA FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zna FirstGlance], [http://www.ebi.ac.uk/pdbsum/5zna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zna ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

The structure of Z-DNA, currently accepted as a model for all left-handed DNAs, fails to provide convincing explanations for at least four well established properties of left-handed DNA polymers in solution. However, the major discrepancies between theory and experiment are resolved by the structure presently proposed for Z[WC]-DNA, a new left-handed, zig-zag double helix with Watson-Crick-type backbone directions. Structural features of Z[WC]-DNA include the presence of an additional H-bond between each guanine N2-amino group and an adjacent phosphate oxygen, the capacity to form four-stranded, base-matched complexes that should readily precipitate from solution, and backbone progressions that are the same as B-DNA (opposite to Z-DNA). However, since Z[WC]-DNA and Z-DNA have many parameters in common, they could be difficult to distinguish in a majority of existing experiments. In view of the close relationship of the new helix to B-DNA, which allows a relatively unhindered right-to-left transition in handedness, Z[WC]-DNA is theorized to be the left-handed structure preferentially generated in vivo by the torque available in naturally occurring DNA supercoils.

~~{{STRUCTURE_5zna| PDB=5zna | SCENE= }}~~

Evidence for a new Z-type left-handed DNA helix: properties of Z(WC)-DNA.,Ansevin AT, Wang AH Nucleic Acids Res. 1990 Oct 25;18(20):6119-26. PMID:2235494<ref>PMID:2235494</ref>

==~~=EVIDENCE FOR A NEW Z-TYPE LEFT~~-~~HANDED DNA HELIX~~: ~~PROPERTIES OF Z(WC)-DNA===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_2235494}}~~

==See Also==

*[[Z-DNA model tour|Z-DNA model tour]]

==~~Reference~~==

== References ==

<~~ref group="xtra">PMID:002235494<~~/~~ref~~><~~references group="xtra"~~/>

__TOC__

</StructureSection>

[[Category: Theoretical Model]]

[[Category: Large Structures]]

[[Category: Ansevin, A T]]

[[Category: Wang, A H]]

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@@ Line 1: / Line 1: @@
 {{Theoretical_model}}
-[[Image:5zna.png|left|200px]]
+==EVIDENCE FOR A NEW Z-TYPE LEFT-HANDED DNA HELIX: PROPERTIES OF Z(WC)-DNA==
+<StructureSection load='5zna' size='340' side='right'caption='[[5zna]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZNA FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zna FirstGlance], [http://www.ebi.ac.uk/pdbsum/5zna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zna ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structure of Z-DNA, currently accepted as a model for all left-handed DNAs, fails to provide convincing explanations for at least four well established properties of left-handed DNA polymers in solution. However, the major discrepancies between theory and experiment are resolved by the structure presently proposed for Z[WC]-DNA, a new left-handed, zig-zag double helix with Watson-Crick-type backbone directions. Structural features of Z[WC]-DNA include the presence of an additional H-bond between each guanine N2-amino group and an adjacent phosphate oxygen, the capacity to form four-stranded, base-matched complexes that should readily precipitate from solution, and backbone progressions that are the same as B-DNA (opposite to Z-DNA). However, since Z[WC]-DNA and Z-DNA have many parameters in common, they could be difficult to distinguish in a majority of existing experiments. In view of the close relationship of the new helix to B-DNA, which allows a relatively unhindered right-to-left transition in handedness, Z[WC]-DNA is theorized to be the left-handed structure preferentially generated in vivo by the torque available in naturally occurring DNA supercoils.
-{{STRUCTURE_5zna|  PDB=5zna  |  SCENE=  }}
+Evidence for a new Z-type left-handed DNA helix: properties of Z(WC)-DNA.,Ansevin AT, Wang AH Nucleic Acids Res. 1990 Oct 25;18(20):6119-26. PMID:2235494<ref>PMID:2235494</ref>
-===EVIDENCE FOR A NEW Z-TYPE LEFT-HANDED DNA HELIX: PROPERTIES OF Z(WC)-DNA===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 5zna" style="background-color:#fffaf0;"></div>
-{{ABSTRACT_PUBMED_2235494}}
+==See Also==
+*[[Z-DNA model tour|Z-DNA model tour]]
-==Reference==
+== References ==
-<ref group="xtra">PMID:002235494</ref><references group="xtra"/>
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Theoretical Model]]
+[[Category: Large Structures]]
 [[Category: Ansevin, A T]]
 [[Category: Wang, A H]]