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[[Image:1a0f.png|left|200px]]


{{STRUCTURE_1a0f| PDB=1a0f | SCENE= }}
==CRYSTAL STRUCTURE OF GLUTATHIONE S-TRANSFERASE FROM ESCHERICHIA COLI COMPLEXED WITH GLUTATHIONESULFONIC ACID==
<StructureSection load='1a0f' size='340' side='right'caption='[[1a0f]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1a0f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A0F FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTS:GLUTATHIONE+SULFONIC+ACID'>GTS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a0f OCA], [https://pdbe.org/1a0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a0f RCSB], [https://www.ebi.ac.uk/pdbsum/1a0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a0f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GSTA_ECOLI GSTA_ECOLI] Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol:disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity.<ref>PMID:7798255</ref> <ref>PMID:2185038</ref> <ref>PMID:17018556</ref> <ref>PMID:18778244</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/1a0f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a0f ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF GLUTATHIONE S-TRANSFERASE FROM ESCHERICHIA COLI COMPLEXED WITH GLUTATHIONESULFONIC ACID===
==See Also==
 
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
{{ABSTRACT_PUBMED_9680481}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1a0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0F OCA].
</StructureSection>
 
[[Category: Escherichia coli K-12]]
==Reference==
[[Category: Large Structures]]
<ref group="xtra">PMID:009680481</ref><references group="xtra"/>
[[Category: Harada S]]
[[Category: Escherichia coli k-12]]
[[Category: Inoue H]]
[[Category: Glutathione transferase]]
[[Category: Nishida M]]
[[Category: Harada, S.]]
[[Category: Noguchi S]]
[[Category: Inoue, H.]]
[[Category: Satow Y]]
[[Category: Nishida, M.]]
[[Category: Takahashi K]]
[[Category: Noguchi, S.]]
[[Category: Satow, Y.]]
[[Category: Takahashi, K.]]
[[Category: Detoxification]]
[[Category: Glutahione conjugation]]
[[Category: Transferase]]
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