1cx4: Difference between revisions

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[[Image:1cx4.png|left|200px]]


{{STRUCTURE_1cx4|  PDB=1cx4  |  SCENE=  }}
==CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE==
 
<StructureSection load='1cx4' size='340' side='right'caption='[[1cx4]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
===CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1cx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The August 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''cAMP-dependent Protein Kinase (PKA)''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_8 10.2210/rcsb_pdb/mom_2012_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CX4 FirstGlance]. <br>
{{ABSTRACT_PUBMED_11342137}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cx4 OCA], [https://pdbe.org/1cx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cx4 RCSB], [https://www.ebi.ac.uk/pdbsum/1cx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cx4 ProSAT]</span></td></tr>
[[1cx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX4 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/KAP3_RAT KAP3_RAT] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/1cx4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cx4 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[CAMP-dependent protein kinase|CAMP-dependent protein kinase]]
*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:011342137</ref><ref group="xtra">PMID:011087674</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Diller, T C.]]
[[Category: Diller TC]]
[[Category: Taylor, S S.]]
[[Category: Taylor SS]]
[[Category: Xuong, N H.]]
[[Category: Xuong NH]]
[[Category: Beta barrel]]
[[Category: Camp-binding]]
[[Category: Camp-dependent protein kinase]]
[[Category: Regulatory subunit]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/1cx4"