1dco: Difference between revisions

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[[Image:1dco.png|left|200px]]


{{STRUCTURE_1dco|  PDB=1dco  |  SCENE=  }}
==DCOH, A BIFUNCTIONAL PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR==
 
<StructureSection load='1dco' size='340' side='right'caption='[[1dco]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===DCOH, A BIFUNCTIONAL PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1dco]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DCO FirstGlance]. <br>
{{ABSTRACT_PUBMED_8897596}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dco OCA], [https://pdbe.org/1dco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dco RCSB], [https://www.ebi.ac.uk/pdbsum/1dco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dco ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1dco]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DCO OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/PHS_RAT PHS_RAT] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.<ref>PMID:1763325</ref> <ref>PMID:8444860</ref>
==Reference==
== Evolutionary Conservation ==
<ref group="xtra">PMID:008897596</ref><references group="xtra"/>
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: 4a-hydroxytetrahydrobiopterin dehydratase]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/1dco_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dco ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Alber, T.]]
[[Category: Alber T]]
[[Category: Cronk, J D.]]
[[Category: Cronk JD]]
[[Category: Endrizzi, J A.]]
[[Category: Endrizzi JA]]
[[Category: 4a-carbinolamine dehydratase]]
[[Category: Dehydratase]]
[[Category: Dimerization cofactor]]
[[Category: Transcriptional stimulator]]
[[Category: Transregulator of homeodomain protein]]
Retrieved from "https://proteopedia.org/1dco"