1d5t: Difference between revisions

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[[Image:1d5t.png|left|200px]]


{{STRUCTURE_1d5t| PDB=1d5t | SCENE= }}
==GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM==
<StructureSection load='1d5t' size='340' side='right'caption='[[1d5t]], [[Resolution|resolution]] 1.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1d5t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D5T FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.04&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5t OCA], [https://pdbe.org/1d5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d5t RCSB], [https://www.ebi.ac.uk/pdbsum/1d5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d5t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GDIA_BOVIN GDIA_BOVIN] Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/1d5t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d5t ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Guanine nucleotide dissociation inhibitor (GDI) is a 55-kDa protein that functions in vesicular membrane transport to recycle Rab GTPases. We have now determined the crystal structure of bovine alpha-GDI at ultra-high resolution (1.04 A). Refinement at this resolution highlighted a region with high mobility of its main-chain residues. This corresponded to a surface loop in the primarily alpha-helical domain II at the base of alpha-GDI containing the previously uncharacterized sequence-conserved region (SCR) 3A. Site-directed mutagenesis showed that this mobile loop plays a crucial role in binding of GDI to membranes and extraction of membrane-bound Rab. This domain, referred to as the mobile effector loop, in combination with Rab-binding residues found in the multi-sheet domain I at the apex of alpha-GDI may provide flexibility for recycling of diverse Rab GTPases. We propose that conserved residues in domains I and II synergize to form the functional face of GDI, and that domain II mediates a critical step in Rab recycling during vesicle fusion.


===GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM===
A new functional domain of guanine nucleotide dissociation inhibitor (alpha-GDI) involved in Rab recycling.,Luan P, Heine A, Zeng K, Moyer B, Greasely SE, Kuhn P, Balch WE, Wilson IA Traffic. 2000 Mar;1(3):270-81. PMID:11208110<ref>PMID:11208110</ref>


{{ABSTRACT_PUBMED_11208110}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1d5t" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
[[1d5t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5T OCA].
*[[Guanine nucleotide dissociation inhibitor|Guanine nucleotide dissociation inhibitor]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011208110</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Balch, W E.]]
[[Category: Large Structures]]
[[Category: Greasley, S E.]]
[[Category: Balch WE]]
[[Category: Heine, A.]]
[[Category: Greasley SE]]
[[Category: Kuhn, P.]]
[[Category: Heine A]]
[[Category: Moyer, B.]]
[[Category: Kuhn P]]
[[Category: Peng, L.]]
[[Category: Moyer B]]
[[Category: Wilson, I A.]]
[[Category: Peng L]]
[[Category: Zeng, K.]]
[[Category: Wilson IA]]
[[Category: Hydrolase inhibitor]]
[[Category: Zeng K]]
Retrieved from "https://proteopedia.org/1d5t"