4hjj: Difference between revisions
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New page: '''Unreleased structure''' The entry 4hjj is ON HOLD Authors: Jakob, C.G., Edalji, R., Judge, R. A., DiGiammarino, E., Li, Y., Gu, J., Ghayur, T. Description: |
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==Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule== | |||
<StructureSection load='4hjj' size='340' side='right'caption='[[4hjj]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hjj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HJJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hjj OCA], [https://pdbe.org/4hjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hjj RCSB], [https://www.ebi.ac.uk/pdbsum/4hjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hjj ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Several bispecific antibody-based formats have been developed over the past 25 years in an effort to produce a new generation of immunotherapeutics that target two or more disease mechanisms simultaneously. One such format, the dual-variable domain immunoglobulin (DVD-Ig), combines the target binding domains of two monoclonal antibodies via flexible naturally occurring linkers, which yields a tetravalent IgG - like molecule. We report the structure of an interleukin (IL)12-IL18 DVD-Ig Fab (DFab) fragment with IL18 bound to the inner variable domain (VD) that reveals the remarkable flexibility of the DVD-Ig molecule and how the DVD-Ig format can function to bind four antigens simultaneously. An understanding of how the inner variable domain retains function is of critical importance for designing DVD-Ig molecules, and for better understanding of the flexibility of immunoglobulin variable domains and linkers, which may aid in the design of improved bi- and multi-specific biologics in general. | |||
Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig) molecule.,Jakob CG, Edalji R, Judge RA, Digiammarino E, Li Y, Gu J, Ghayur T MAbs. 2013 Apr 2;5(3). PMID:23549062<ref>PMID:23549062</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4hjj" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Interleukin 3D structures|Interleukin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: DiGiammarino E]] | |||
[[Category: Edalji R]] | |||
[[Category: Ghayur T]] | |||
[[Category: Gu J]] | |||
[[Category: Jakob CG]] | |||
[[Category: Judge RA]] | |||
[[Category: Li Y]] | |||
Latest revision as of 02:59, 21 November 2024
Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule
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