4hld: Difference between revisions
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New page: '''Unreleased structure''' The entry 4hld is ON HOLD Authors: Olivier, N. Description: Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK):... |
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==Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 11== | |||
<StructureSection load='4hld' size='340' side='right'caption='[[4hld]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hld]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16T:1-[(3S)-1-{[3-(3-CHLOROPHENOXY)-4-HYDROXYPHENYL]SULFONYL}PIPERIDIN-3-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>16T</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hld OCA], [https://pdbe.org/4hld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hld RCSB], [https://www.ebi.ac.uk/pdbsum/4hld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hld ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KTHY_STAAR KTHY_STAAR] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity). | |||
==See Also== | |||
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus subsp. aureus MRSA252]] | |||
[[Category: Olivier N]] | |||
Latest revision as of 11:42, 1 March 2024
Sulfonylpiperidines as Novel, Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase (TMK): Compound 11
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