2i1t: Difference between revisions

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[[Image:2i1t.png|left|200px]]


{{STRUCTURE_2i1t|  PDB=2i1t  |  SCENE=  }}
==Solution structure of Jingzhaotoxin-III, a novel toxin inhibiting both Nav and Kv channels==
 
<StructureSection load='2i1t' size='340' side='right'caption='[[2i1t]]' scene=''>
===Solution structure of Jingzhaotoxin-III, a novel toxin inhibiting both Nav and Kv channels===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2i1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chilobrachys_guangxiensis Chilobrachys guangxiensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1T FirstGlance]. <br>
{{ABSTRACT_PUBMED_15084603}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1t OCA], [https://pdbe.org/2i1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1t RCSB], [https://www.ebi.ac.uk/pdbsum/2i1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1t ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2i1t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chilobrachys_guangxiensis Chilobrachys guangxiensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1T OCA].  
== Function ==
[https://www.uniprot.org/uniprot/JZTX3_CHIGU JZTX3_CHIGU] Selectively inhibits activation of voltage-gated sodium channels (VGSC) (Nav1.5/SCN5A) in rat cardiac myocytes, followed by shifting activated voltage in a depolarizing direction. The binding site on VGSC is suggested to be site 4 located at the extracellular S3-S4 loop of the channel. Also binds to voltage-gated potassium channels (Kv2.1/KCNB1).<ref>PMID:17150181</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chilobrachys guangxiensis]]
[[Category: Chilobrachys guangxiensis]]
[[Category: Liang, S.]]
[[Category: Large Structures]]
[[Category: Liao, Z.]]
[[Category: Liang S]]
[[Category: Peng, K.]]
[[Category: Liao Z]]
[[Category: Cardiac myocyte]]
[[Category: Peng K]]
[[Category: Jingzhaotoxin-iii]]
[[Category: Kv2 1 channel]]
[[Category: Nav channel]]
[[Category: Solution structure]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/2i1t"