2m04: Difference between revisions
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==Solution structure of BCL-xL in complex with PUMA BH3 peptide== | |||
<StructureSection load='2m04' size='340' side='right'caption='[[2m04]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2m04]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M04 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m04 OCA], [https://pdbe.org/2m04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m04 RCSB], [https://www.ebi.ac.uk/pdbsum/2m04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m04 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | |||
==See Also== | |||
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Kriwacki RW]] | |||
[[Category: Royappa G]] | |||
[[Category: Viacava Follis A]] | |||
Latest revision as of 06:58, 1 May 2024
Solution structure of BCL-xL in complex with PUMA BH3 peptide
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