4hp3: Difference between revisions
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New page: '''Unreleased structure''' The entry 4hp3 is ON HOLD Authors: Chao, X., Tempel, W., Bian, C., Bountra, C., Arrowsmith, C. H., Edwards, A. M., Min, J., Structural Genomics Consortium (SG... |
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==Crystal structure of Tet3 in complex with a CpG dsDNA== | |||
<StructureSection load='4hp3' size='340' side='right'caption='[[4hp3]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hp3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HP3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hp3 OCA], [https://pdbe.org/4hp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hp3 RCSB], [https://www.ebi.ac.uk/pdbsum/4hp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hp3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TET3_XENTR TET3_XENTR] Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Conversion of 5mC into 5hmC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes, including pax6, rax, sox9 and six3. May also contribute to the regulation of target genes in ways that do not require its enzyme activity.<ref>PMID:23217707</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Xenopus tropicalis]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bian C]] | |||
[[Category: Bountra C]] | |||
[[Category: Chao X]] | |||
[[Category: Edwards AM]] | |||
[[Category: Min J]] | |||
[[Category: Tempel W]] | |||
Latest revision as of 11:42, 1 March 2024
Crystal structure of Tet3 in complex with a CpG dsDNA
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