4g13: Difference between revisions
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==Crystal structure of samarosporin I at 100K== | |||
<StructureSection load='4g13' size='340' side='right'caption='[[4g13]], [[Resolution|resolution]] 0.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4g13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Samarospora_rostrup Samarospora rostrup]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G13 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DIV:D-ISOVALINE'>DIV</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=PHL:L-PHENYLALANINOL'>PHL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g13 OCA], [https://pdbe.org/4g13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g13 RCSB], [https://www.ebi.ac.uk/pdbsum/4g13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g13 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The atomic resolution structures of samarosporin I have been determined at 100 and 293 K. This is the first crystal structure of a natural 15-residue peptaibol. The amino acid sequence in samarosporin I is identical to emerimicin IV and stilbellin I. Samarosporin is a peptide antibiotic produced by the ascomycetous fungus Samarospora rostrup and belongs to peptaibol subfamily 2. The structures at both temperatures are very similar to each other adopting mainly a 3(10) -helical and a minor fraction of alpha-helical conformation. The helices are significantly bent and packed in an antiparallel fashion in the centered monoclinic lattice leaving among them an approximately 10-A channel extending along the crystallographic twofold axis. Only two ordered water molecules per peptide molecule were located in the channel. Comparisons have been carried out with crystal structures of subfamily 2 16-residue peptaibols antiamoebin and cephaibols. The repercussion of the structural analysis of samarosporin on membrane function is discussed. Copyright (c) 2012 European Peptide Society and John Wiley & Sons, Ltd. | |||
The crystal structure of samarosporin I at atomic resolution.,Gessmann R, Axford D, Evans G, Bruckner H, Petratos K J Pept Sci. 2012 Nov;18(11):678-84. doi: 10.1002/psc.2454. Epub 2012 Sep 28. PMID:23019149<ref>PMID:23019149</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== | <div class="pdbe-citations 4g13" style="background-color:#fffaf0;"></div> | ||
[[ | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Samarospora rostrup]] | [[Category: Samarospora rostrup]] | ||
[[Category: Axford | [[Category: Axford D]] | ||
[[Category: Gessmann | [[Category: Gessmann R]] | ||
[[Category: Petratos | [[Category: Petratos K]] | ||
Latest revision as of 22:54, 26 March 2025
Crystal structure of samarosporin I at 100K
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