3v4y: Difference between revisions

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[[Image:3v4y.jpg|left|200px]]


{{STRUCTURE_3v4y|  PDB=3v4y  |  SCENE=  }}
==Crystal Structure of the first Nuclear PP1 holoenzyme==
 
<StructureSection load='3v4y' size='340' side='right'caption='[[3v4y]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Crystal Structure of the first Nuclear PP1 holoenzyme===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3v4y]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V4Y FirstGlance]. <br>
{{ABSTRACT_PUBMED_22940584}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.098&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4y OCA], [https://pdbe.org/3v4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v4y RCSB], [https://www.ebi.ac.uk/pdbsum/3v4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4y ProSAT]</span></td></tr>
[[3v4y]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4Y OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PP1R8_HUMAN PP1R8_HUMAN] Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.  Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Large Structures]]
[[Category: Connell, N E.O.]]
[[Category: Nichols S]]
[[Category: Nichols, S.]]
[[Category: O'Connell NE]]
[[Category: Page, R.]]
[[Category: Page R]]
[[Category: Peti, W.]]
[[Category: Peti W]]
[[Category: Hydrolase]]
[[Category: Idp]]
[[Category: Nipp1]]
[[Category: Pp1]]
[[Category: Ser/thr phosphatase]]
Retrieved from "https://proteopedia.org/3v4y"