1dtv: Difference between revisions

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[[Image:1dtv.png|left|200px]]


{{STRUCTURE_1dtv| PDB=1dtv |  SCENE= }}
==NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI)==
<StructureSection load='1dtv' size='340' side='right'caption='[[1dtv]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1dtv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DTV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dtv OCA], [https://pdbe.org/1dtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dtv RCSB], [https://www.ebi.ac.uk/pdbsum/1dtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dtv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCPI_HIRME MCPI_HIRME] Tightly binding, competitive inhibitor of different types of pancreatic-like carboxypeptidases.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Leech carboxypeptidase inhibitor (LCI) is a novel protein inhibitor present in the medicinal leech Hirudo medicinalis. The structures of LCI free and bound to carboxypeptidase A2 (CPA2)have been determined by NMR and X-ray crystallography, respectively. The LCI structure defines a new protein motif that comprises a five-stranded antiparallel beta-sheet and one short alpha-helix. This structure is preserved in the complex with human CPA2 in the X-ray structure, where the contact regions between the inhibitor and the protease are defined. The C-terminal tail of LCI becomes rigid upon binding the protease as shown in the NMR relaxation studies, and it interacts with the carboxypeptidase in a substrate-like manner. The homology between the C-terminal tails of LCI and the potato carboxypeptidase inhibitor represents a striking example of convergent evolution dictated by the target protease. These new structures are of biotechnological interest since they could elucidate the control mechanism of metallo-carboxypeptidases and could be used as lead compounds for the search of fibrinolytic drugs.


===NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI)===
Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.,Reverter D, Fernandez-Catalan C, Baumgartner R, Pfander R, Huber R, Bode W, Vendrell J, Holak TA, Aviles FX Nat Struct Biol. 2000 Apr;7(4):322-8. PMID:10742178<ref>PMID:10742178</ref>


{{ABSTRACT_PUBMED_10742178}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 1dtv" style="background-color:#fffaf0;"></div>
[[1dtv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTV OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:010742178</ref><references group="xtra"/>
</StructureSection>
[[Category: Hirudo medicinalis]]
[[Category: Hirudo medicinalis]]
[[Category: Aviles, F X.]]
[[Category: Large Structures]]
[[Category: Bode, W.]]
[[Category: Aviles FX]]
[[Category: Fernandez-Catalan, C.]]
[[Category: Bode W]]
[[Category: Holak, T A.]]
[[Category: Fernandez-Catalan C]]
[[Category: Reverter, D.]]
[[Category: Holak TA]]
[[Category: Hydrolase inhibitor]]
[[Category: Reverter D]]
[[Category: Lci]]
[[Category: Leech carboxypeptidase inhibitor]]
Retrieved from "https://proteopedia.org/1dtv"