Fructokinase: Difference between revisions

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~~{{STRUCTURE_3lki| PDB~~=~~3lki | SIZE~~=~~400| SCENE~~= |right~~|CAPTION~~=~~Se-Met fructokinase complex~~ with ~~fructose, ATP, sulfate~~ and ~~Zn+2 ion,~~ [[~~3lki~~]] }}

~~<!--~~

== Function ==

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'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors.

'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors<ref>PMID:3009653</ref>.

*<scene name='48/484862/Cv/6'>Fructokinase with ADP and fructose bound in the active site</scene> ([[3lm9]]). Water molecules shown as red spheres.

== Relevance ==

Inhibitors of FRK C may block sugar-associated metabolic syndromes<ref>PMID:23439477</ref>.

== Disease ==

FRK deficiency in the liver causes the inherited metabolic disorder Fructosuria<ref>PMID:2992452</ref>.

</StructureSection>

==3D structures of fructokinase==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[2qhp]] – FRK – ''Bacterioides thetaiotamicron''

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[[3lki]] – XfFRK + ATP

[[3lm9]] - BsFRK + ATP + fructose – ''Bacillus subtilis''

[[3ohr]] - BsFRK + ADP

[[3ohr]] - BsFRK + ADP

[[2v78]], [[2var]] – FRK – ''Sulfolobus solfataricus''

[[3c8u]] – FRK – ''Silicibacter''

[[5ey7]] – VcFRK – ''Vibrio cholerae''

[[5f11]] – VcFRK + fructose

[[5f0z]], [[5ygg]] – VcFRK + fructose + ADP

[[5eyn]] – VcFRK + fructose + ADP + BeF3

[[7cf8]], [[7cfa]] – FRK – ''Mycobacterium marinum''

[[4u7x]] – BaFRK – ''Brucella abortus''

[[4wjm]] – BaFRK + AMPPNP

For Hepatic fructokinase see [[Ketohexokinase]]

== References ==

[[Category:Topic Page]]

Fructokinase: Difference between revisions

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3lki|  PDB=3lki  | SIZE=400| SCENE= |right|CAPTION=Se-Met fructokinase complex with fructose, ATP, sulfate and Zn+2 ion, [[3lki]] }}
+<StructureSection load='' size='350' side='right' scene='48/484862/Cv/2' caption='Fructokinase with ADP and Fructose bound in the active site [[3lm9]]'>
-<!--
+== Function ==
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
-Or use the four-green-boxes-button to insert scrollable text adjacent
-to a Jmol applet. Check out the other buttons as well!
--->
-'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals.  In plants and bacteria FRK regulates starch synthesis.  In animals it produces oxalate and its precursors.
+'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals.  In plants and bacteria FRK regulates starch synthesis.  In animals it produces oxalate and its precursors<ref>PMID:3009653</ref>.
+*<scene name='48/484862/Cv/6'>Fructokinase with ADP and fructose bound in the active site</scene> ([[3lm9]]). Water molecules shown as red spheres.
+== Relevance ==
+Inhibitors of FRK C may block sugar-associated metabolic syndromes<ref>PMID:23439477</ref>.
+== Disease ==
+FRK deficiency in the liver causes the inherited metabolic disorder Fructosuria<ref>PMID:2992452</ref>.
+</StructureSection>
 ==3D structures of fructokinase==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 [[2qhp]] – FRK – ''Bacterioides thetaiotamicron''<br />
@@ Line 15: / Line 22: @@
 [[3lki]] – XfFRK + ATP<br />
 [[3lm9]] - BsFRK + ATP + fructose – ''Bacillus subtilis''<br />
-[[3ohr]] - BsFRK + ADP
+[[3ohr]] - BsFRK + ADP<br />
+[[2v78]], [[2var]] – FRK – ''Sulfolobus solfataricus''<br />
+[[3c8u]] – FRK – ''Silicibacter''<br />
+[[5ey7]] – VcFRK – ''Vibrio cholerae''<br />
+[[5f11]] – VcFRK + fructose <br />
+[[5f0z]], [[5ygg]] – VcFRK + fructose + ADP<br />
+[[5eyn]] – VcFRK + fructose + ADP + BeF3<br />
+[[7cf8]], [[7cfa]] – FRK – ''Mycobacterium marinum''<br />
+[[4u7x]] – BaFRK – ''Brucella abortus''<br />
+[[4wjm]] – BaFRK + AMPPNP<br />
+For Hepatic fructokinase see [[Ketohexokinase]]
+== References ==
+<references/>
 [[Category:Topic Page]]