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| [[Image:1pm3.gif|left|200px]]<br /><applet load="1pm3" size="350" color="white" frame="true" align="right" spinBox="true"
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| caption="1pm3, resolution 3.15Å" />
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| '''MTH1859'''<br />
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| ==Overview== | | ==MTH1859== |
| MTH1859 from Methanobacterium thermoautotrophicum is a 77 residue protein representing a conserved family of functionally uncharacterized proteins. We solved the crystal structure of MTH1859 by single wavelength anomalous diffraction phasing using selenomethionine labeled protein. MTH1859 adopts a mainly anti-parallel all-beta-fold. The beta-sheet is heavily bent to form a U-structure that is closed through a loop. The monomer structure possesses similarities to the photoreaction center (PRC) domain fold, but the protein employs a unique oligomerization scheme. Two monomers of MTH1859 occupy the asymmetric unit and dimerize in a head-to-head fashion. Crystal packing interactions identify a second protein-protein interaction interface at the MTH1859 tails which can simultaneously bind two partner molecules. These interactions lead to the formation of a honeycomb structure and suggest that the family of MTH1859-like proteins might function as adapters for protein complex assembly.
| | <StructureSection load='1pm3' size='340' side='right'caption='[[1pm3]], [[Resolution|resolution]] 3.15Å' scene=''> |
| | | == Structural highlights == |
| ==About this Structure== | | <table><tr><td colspan='2'>[[1pm3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PM3 FirstGlance]. <br> |
| 1PM3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PM3 OCA].
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15Å</td></tr> |
| | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pm3 OCA], [https://pdbe.org/1pm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pm3 RCSB], [https://www.ebi.ac.uk/pdbsum/1pm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pm3 ProSAT], [https://www.topsan.org/Proteins/NESGC/1pm3 TOPSAN]</span></td></tr> |
| ==Reference== | | </table> |
| Crystal structure of the putative adapter protein MTH1859., Ye H, Chen TC, Xu X, Pennycooke M, Wu H, Steegborn C, J Struct Biol. 2004 Nov;148(2):251-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15477104 15477104]
| | == Function == |
| | [https://www.uniprot.org/uniprot/O27887_METTH O27887_METTH] |
| | __TOC__ |
| | </StructureSection> |
| | [[Category: Large Structures]] |
| [[Category: Methanothermobacter thermautotrophicus]] | | [[Category: Methanothermobacter thermautotrophicus]] |
| [[Category: Single protein]]
| | [[Category: Steegborn C]] |
| [[Category: NESG, Northeast Structural Genomics Consortium.]]
| | [[Category: Wu H]] |
| [[Category: Steegborn, C.]] | | [[Category: Ye H]] |
| [[Category: Wu, H.]] | |
| [[Category: Ye, H.]] | |
| [[Category: nesg]]
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| [[Category: northeast structural genomics consortium]]
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| [[Category: protein structure initiative]]
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| [[Category: psi]]
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| [[Category: structural genomics]]
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| [[Category: unknown function]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:30:09 2008''
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