Granzyme: Difference between revisions

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<StructureSection load='1fq3' size='400' side='right' caption='Structure of glycosylated human granzyme B dimer complex with sulfate (PDB entry [[1fq3]])' scene=''>
<StructureSection load='1iau' size='400' side='right' caption='Structure of glycosylated human granzyme B (green) complex with pentapeptide inhibitor (magenta) and Zn+2 ions (grey) (PDB entry [[1iau]])' scene='51/517375/Cv/1'>
== Function ==
'''Granzymes''' (GZM) or '''cytotoxic T-lymphocyte proteinase 1''' are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br />
*'''Granzyme A''' is the most abundant serine protease in killer cells cytotoxic granules <ref>PMID:20536557</ref>.<br />
*'''Granzyme B and C''' induce cytotoxic T lymphocyte-mediated target cell apoptosis <ref>PMID:12752668</ref>.<br />
*'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br />
*'''Granzyme K''' functions in a similar way to granzyme A <ref>PMID:19059912</ref>.<br />
*'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br />


'''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells.
== Structural highlights ==
The <scene name='51/517375/Cv/6'>active site</scene> of human GZMB contains the <scene name='51/517375/Cv/7'>typical serine protease catalytic triad</scene> and <scene name='51/517375/Cv/8'>oxyanion hole</scene><ref>PMID:11325591</ref>.
</StructureSection>


==3D structures of granzyme==
==3D structures of granzyme==


===Granzyme A===
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
{{#tree:id=OrganizedByTopic|openlevels=0|
[[1op8]] – hGZM<br />
[[1orf]] – hGZM (mutant)
 
===Granzyme B===


[[1fi8]] – GZM (mutant) + ecotin – rat<br />
*Granzyme A
[[1fq3]] – hGZM<br />
[[1iau]] – hGZM + polypeptide<br />


===Granzyme C===
**[[1op8]] – hGZM<br />
**[[1orf]] – hGZM (mutant)


[[3fzz]] – mGZM – mouse<br />
*Granzyme B
[[3g01]] –  mGZM (mutant)


===Granzyme H===
**[[1fi8]] – GZM (mutant) + ecotin – rat<br />
**[[1fq3]] – hGZM<br />
**[[1iau]] – hGZM + polypeptide<br />


[[3tk9]] - hGZM (mutant) <br />
*Granzyme C
[[3tju]], [[3tjv]] - hGZM (mutant) + polypeptide<br />


===Granzyme K===
**[[3fzz]] – mGZM – mouse<br />
**[[3g01]] –  mGZM (mutant)


[[1mza]], [[1mzd]] – h-proGZM (mutant)
*Granzyme H


===Granzyme M===
**[[4gaw]] – hGZM<br />
**[[3tk9]] - hGZM (mutant) <br />
**[[3tju]], [[3tjv]] - hGZM (mutant) + polypeptide<br />


[[2zgc]] – hGZM<br />
*Granzyme K
[[2zgh]], [[2zks]] - hGZM + polypeptide<br />
[[2zgj]] – hGZM (mutant) + polypeptide<br />


**[[1mza]], [[1mzd]] – h-proGZM (mutant)


*Granzyme M


**[[2zgc]] – hGZM<br />
**[[2zgh]], [[2zks]] - hGZM + polypeptide<br />
**[[2zgj]] – hGZM (mutant) + polypeptide<br />
}}
== References ==
<references/>


[[Category:Topic Page]]
</StructureSection>
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