Homocitrate synthase: Difference between revisions
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<StructureSection load='3ivt' size='400' side='right' scene='46/465446/Cv/1' caption='Fission yeast homocitrate synthase Lys4 dimer complex with 2-oxoglutarate, Na+ (purple) and Zn+2 (grey) ions [[3ivt]]'> | |||
'''Homocitrate synthase''' (HS) participates in lysine biosynthesis and pyruvate metabolism. HS catalyzes the conversion of acetyl-CoA + H2O + 2-oxoglutarate to 2-hydroxybutane-1,2,4-tricarboxylate + CoA. | == Function == | ||
'''Homocitrate synthase''' (HS) participates in lysine biosynthesis and pyruvate metabolism. HS catalyzes the conversion of acetyl-CoA + H2O + 2-oxoglutarate to 2-hydroxybutane-1,2,4-tricarboxylate + CoA<ref>PMID:5836514</ref>. | |||
== Structural highlights == | |||
The HS <scene name='46/465446/Cv/7'>active site is located in the interior of the N-terminal TIM-barrel domain</scene>. | |||
*<scene name='46/465446/Cv/8'>Active site</scene>. | |||
*The <scene name='46/465446/Cv/9'>metal ion is octahedrally coordinated to the protein and to the 2-oxoglutarate</scene><ref>PMID:19776021</ref>. Water molecules shown as red spheres. | |||
</StructureSection> | |||
== 3D Structures of homocitrate synthase == | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[3ivs]] – fyHS Lys4 – fission yeast<br /> | [[3ivs]] – fyHS Lys4 – fission yeast<br /> | ||
[[3ivt]], [[3ivu]] - fyHS Lys4 + 2- | [[3ivt]], [[3ivu]] - fyHS Lys4 + 2-oxoglutarate<br /> | ||
[[3mi3]] - fyHS Lys4 + lysine<br /> | [[3mi3]] - fyHS Lys4 + lysine<br /> | ||
[[2ztj]] – TtHS + α-ketoglutarate – ''Thermus thermophilus''<br /> | [[2ztj]] – TtHS + α-ketoglutarate – ''Thermus thermophilus''<br /> | ||
[[2zyf]] - TtHS + α-ketoglutarate + Mg<br /> | [[2zyf]] - TtHS + α-ketoglutarate + Mg<br /> | ||
[[2ztk]] – TtHS + homocitrate<br /> | [[2ztk]] – TtHS + homocitrate<br /> | ||
[[3a9i]] – TtHS + lysine | [[3a9i]] – TtHS + lysine<br /> | ||
[[6ktq]] - HS + -ketoglutarate + CoA – ''Sulfolobus acidocaldarius''<br /> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 08:43, 27 September 2021
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3D Structures of homocitrate synthase
Updated on 27-September-2021
3ivs – fyHS Lys4 – fission yeast
3ivt, 3ivu - fyHS Lys4 + 2-oxoglutarate
3mi3 - fyHS Lys4 + lysine
2ztj – TtHS + α-ketoglutarate – Thermus thermophilus
2zyf - TtHS + α-ketoglutarate + Mg
2ztk – TtHS + homocitrate
3a9i – TtHS + lysine
6ktq - HS + -ketoglutarate + CoA – Sulfolobus acidocaldarius
