Neuroglobin: Difference between revisions

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[[Image:1oj6.png|left|200px|thumb|Crystal Structure of Human Neuroglobin [[1oj6]]]]
<StructureSection load='' size='400' side='right' scene='44/443478/Cv/2' caption='Mouse neuroglobin showing the heme and complexed with sulfate and Xe [[3gk9]]' pspeed='8'>
{{STRUCTURE_3gk9|  PDB=3gk9  | SIZE=400| SCENE= |right|CAPTION=Mouse neuroglobin showing the heme and complexed with sulfate and Xe [[3gk9]] }}
{{TOC limit|limit=2}}


== Function ==
'''Neuroglobin''' (NGB) is involved in cellular oxygen homeostasis.  It binds oxygen reversibly.  It increases oxygen availability in the brain.  It is a monomer containing a heme group<ref>PMID:15298922</ref>.


== Relevance ==
NGB may influence the course of Alzhheimer's disease<ref>PMID:23648513</ref>.


 
== Structural highlights ==
 
*<scene name='44/443478/Cv/15'>Heme binding site</scene>. Water molecules are shown as red spheres.
 
*<scene name='44/443478/Cv/16'>1st Xe coordination site</scene>.
 
*<scene name='44/443478/Cv/17'>2nd Xe coordination site</scene>.
 
*<scene name='44/443478/Cv/18'>3rd Xe binding site</scene>.
 
*<scene name='44/443478/Cv/19'>4th Xe binding site</scene>.
 
</StructureSection>
 
 
 
 
 
 
 
 
 
'''Neuroglobin''' (NGB) is involved in cellular oxygen homeostasis. It binds oxygen reversibly.  It increases oxygen availability in the brain.  It is a monomer containing a heme group.
 
 
== 3D Structures of Neuroglobin ==
== 3D Structures of Neuroglobin ==


[[3gk9]], [[3gkt]], [[2vry]], [[1q1f]] – mNGB (mutant) – mouse<br />
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[3gln]], [[1w92]] – mNGB (mutant) + CO<br />
[[1oj6]] – NGB (mutant) - human


[[4mpm]] – hNGB - human<br />
[[1oj6]], [[7vqg]], [[8grz]], [[8wub]] – hNGB (mutant)
[[5eet]], [[6r1q]] – mNGB – mouse<br />
[[1q1f]], [[2vry]], [[3gk9]], [[3gkt]], [[4mu5]], [[4nzi]], [[4o1t]], [[4o4t]], [[5eoh]], [[5eqm]], [[5eu2]], [[5ev5]], [[5eyj]], [[5eys]], [[5f0b]], [[5f2a]], [[5nvi]], [[5nw6]], [[5o17]], [[5o18]], [[5o1k]], [[5o27]], [[6eye]], [[6h5z]], [[6h6c]], [[6h6i]], [[6ra6]], [[7ohd]] – mNGB (mutant)
[[6i3t]], [[6i40]] – mNGB + CO<br />
[[1w92]], [[3gln]], [[4o2g]], [[4o35]], [[6h6j]] – mNGB (mutant) + CO
[[4o4z]] – mNGB (mutant) + N<sub>2</sub>O<br />
[[5mjc]], [[5mjd]] – mNGB + O<sub>2</sub><br />
[[4b4y]] – NGB – ''Symsagittifera roscoffensis''<br />
== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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