2yps: Difference between revisions

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New page: '''Unreleased structure''' The entry 2yps is ON HOLD Authors: Canning, P., Kiyani, W., Froese, D.S., Krojer, T., Strain-Damerell, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bou...
 
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'''Unreleased structure'''


The entry 2yps is ON HOLD
==Crystal structure of the PX domain of human sorting nexin 3==
<StructureSection load='2yps' size='340' side='right'caption='[[2yps]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2yps]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yps OCA], [https://pdbe.org/2yps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yps RCSB], [https://www.ebi.ac.uk/pdbsum/2yps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yps ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN] MMEP syndrome. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12).
== Function ==
[https://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN] Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation.<ref>PMID:11433298</ref> <ref>PMID:18767904</ref>


Authors: Canning, P., Kiyani, W., Froese, D.S., Krojer, T., Strain-Damerell, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Yue, W.W.
==See Also==
 
*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
Description: Crystal structure of the PX domain of human sorting nexin 3
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Canning P]]
[[Category: Edwards AM]]
[[Category: Froese DS]]
[[Category: Kiyani W]]
[[Category: Krojer T]]
[[Category: Strain-Damerell C]]
[[Category: Yue WW]]
[[Category: Von Delft F]]
Retrieved from "https://proteopedia.org/2yps"