1mr0: Difference between revisions

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[[Image:1mr0.png|left|200px]]


{{STRUCTURE_1mr0|  PDB=1mr0  |  SCENE=  }}
==SOLUTION NMR STRUCTURE OF AGRP(87-120; C105A)==
 
<StructureSection load='1mr0' size='340' side='right'caption='[[1mr0]]' scene=''>
===SOLUTION NMR STRUCTURE OF AGRP(87-120; C105A)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1mr0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mc6 1mc6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MR0 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mr0 OCA], [https://pdbe.org/1mr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mr0 RCSB], [https://www.ebi.ac.uk/pdbsum/1mr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mr0 ProSAT]</span></td></tr>
[[1mr0]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mc6 1mc6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR0 OCA].  
</table>
 
== Disease ==
==Reference==
[https://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN] Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:12213871</ref>
<ref group="xtra">PMID:012056887</ref><references group="xtra"/>
== Function ==
[[Category: Barsh, G S.]]
[https://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN] Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.<ref>PMID:9892020</ref> <ref>PMID:11145747</ref> <ref>PMID:17041250</ref> <ref>PMID:10371151</ref> <ref>PMID:15927146</ref>
[[Category: Chai, B.]]
== Evolutionary Conservation ==
[[Category: Gantz, I.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Jackson, P J.]]
Check<jmol>
[[Category: Mcnulty, J C.]]
  <jmolCheckbox>
[[Category: Millhauser, G M.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mr0_consurf.spt"</scriptWhenChecked>
[[Category: Thompson, D A.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Yang, Y K.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Agouti-related protein]]
  </jmolCheckbox>
[[Category: Agrp]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mr0 ConSurf].
[[Category: Ick]]
<div style="clear:both"></div>
[[Category: Inhibitor cystine knot]]
== References ==
[[Category: Melanocortin]]
<references/>
[[Category: Rational protein design]]
__TOC__
[[Category: Signaling protein]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Barsh GS]]
[[Category: Chai B]]
[[Category: Gantz I]]
[[Category: Jackson PJ]]
[[Category: Mcnulty JC]]
[[Category: Millhauser GM]]
[[Category: Thompson DA]]
[[Category: Yang YK]]
Retrieved from "https://proteopedia.org/1mr0"