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[[Image:1ek2.png|left|200px]]


{{STRUCTURE_1ek2| PDB=1ek2 | SCENE= }}
==CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR==
<StructureSection load='1ek2' size='340' side='right'caption='[[1ek2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ek2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EK2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDU:N-CYCLOHEXYL-N-DECYLUREA'>CDU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ek2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ek2 OCA], [https://pdbe.org/1ek2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ek2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ek2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ek2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HYES_MOUSE HYES_MOUSE] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ek/1ek2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ek2 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR===
==See Also==
 
*[[Epoxide hydrolase 3D structures|Epoxide hydrolase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
[[1ek2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EK2 OCA].
[[Category: Large Structures]]
 
==Reference==
<ref group="xtra">PMID:010747889</ref><references group="xtra"/>
[[Category: Hydrolase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Argiriadi, M A.]]
[[Category: Argiriadi MA]]
[[Category: Christianson, D W.]]
[[Category: Christianson DW]]
[[Category: Dowdy, D L.]]
[[Category: Dowdy DL]]
[[Category: Goodrow, M H.]]
[[Category: Goodrow MH]]
[[Category: Hammock, B D.]]
[[Category: Hammock BD]]
[[Category: Morisseau, C.]]
[[Category: Morisseau C]]
[[Category: Alpha/beta hydrolase fold]]
[[Category: Disubstituted urea inhibitor]]
[[Category: Homodimer]]
[[Category: Hydrolase]]
Retrieved from "https://proteopedia.org/1ek2"