1eog: Difference between revisions
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==CRYSTAL STRUCTURE OF PI CLASS GLUTATHIONE TRANSFERASE== | |||
<StructureSection load='1eog' size='340' side='right'caption='[[1eog]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1eog]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EOG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eog OCA], [https://pdbe.org/1eog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eog RCSB], [https://www.ebi.ac.uk/pdbsum/1eog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eog ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/1eog_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eog ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | |||
== References == | |||
<references/> | |||
[[ | __TOC__ | ||
</StructureSection> | |||
== | |||
< | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Aceto | [[Category: Large Structures]] | ||
[[Category: Cocco | [[Category: Aceto A]] | ||
[[Category: Dragani | [[Category: Cocco R]] | ||
[[Category: Mannervik | [[Category: Dragani B]] | ||
[[Category: McKinstry | [[Category: Mannervik B]] | ||
[[Category: Oakley | [[Category: McKinstry WJ]] | ||
[[Category: Parker | [[Category: Oakley AJ]] | ||
[[Category: Rossjohn | [[Category: Parker MW]] | ||
[[Category: Stenberg | [[Category: Rossjohn J]] | ||
[[Category: Stenberg G]] | |||
Latest revision as of 07:05, 7 February 2024
CRYSTAL STRUCTURE OF PI CLASS GLUTATHIONE TRANSFERASE
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