4esr: Difference between revisions
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==Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors== | |||
<StructureSection load='4esr' size='340' side='right'caption='[[4esr]], [[Resolution|resolution]] 1.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4esr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ESR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
[[4esr]] is a 2 chain structure with sequence from [ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4esr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esr OCA], [https://pdbe.org/4esr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4esr RCSB], [https://www.ebi.ac.uk/pdbsum/4esr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4esr ProSAT]</span></td></tr> | ||
</table> | |||
== | == Disease == | ||
< | [https://www.uniprot.org/uniprot/AHI1_HUMAN AHI1_HUMAN] Joubert syndrome;Joubert syndrome with ocular defect. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/AHI1_HUMAN AHI1_HUMAN] Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Jiang X]] | ||
[[Category: | [[Category: Liu PX]] | ||
[[Category: | [[Category: Lobo P]] | ||
[[Category: | [[Category: Van Petegem XF]] | ||
Latest revision as of 11:05, 1 March 2024
Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors
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