4fwz: Difference between revisions

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[[Image:4fwz.png|left|200px]]


{{STRUCTURE_4fwz| PDB=4fwz | SCENE= }}
==Aquoferric CuB myoglobin (L29H F43H sperm whale myoglobin)==
<StructureSection load='4fwz' size='340' side='right'caption='[[4fwz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fwz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FWZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fwz OCA], [https://pdbe.org/4fwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fwz RCSB], [https://www.ebi.ac.uk/pdbsum/4fwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fwz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
No spare Tyr: Rational design of functional enzymes with a high number of turnovers is a challenge, especially those with a complex active site, such as respiratory oxidases. Introducing two His and one Tyr residues into myoglobin resulted in enzymes that reduce O(2) to H(2) O with more than 1000 turnovers (red line, see scheme) and minimal release of reactive oxygen species. The positioning of the Tyr residue is critical for activity.


===Aquoferric CuB myoglobin (L29H F43H sperm whale myoglobin)===
A Designed Functional Metalloenzyme that Reduces O(2) to H(2) O with Over One Thousand Turnovers.,Miner KD, Mukherjee A, Gao YG, Null EL, Petrik ID, Zhao X, Yeung N, Robinson H, Lu Y Angew Chem Int Ed Engl. 2012 Jun 4;51(23):5589-92. doi: 10.1002/anie.201201981., Epub 2012 Apr 26. PMID:22539151<ref>PMID:22539151</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4fwz" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
[[4fwz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWZ OCA].
*[[Myoglobin 3D structures|Myoglobin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022539151</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Physeter catodon]]
[[Category: Physeter catodon]]
[[Category: Gao, Y G.]]
[[Category: Gao Y-G]]
[[Category: Lu, Y.]]
[[Category: Lu Y]]
[[Category: Miner, K D.]]
[[Category: Miner KD]]
[[Category: Petrik, I D.]]
[[Category: Petrik ID]]
[[Category: Robinson, H.]]
[[Category: Robinson H]]
[[Category: Globin]]
[[Category: Oxidase]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/4fwz"