4gh6: Difference between revisions

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[[Image:4gh6.png|left|200px]]


{{STRUCTURE_4gh6| PDB=4gh6 | SCENE= }}
==Crystal structure of the PDE9A catalytic domain in complex with inhibitor 28==
<StructureSection load='4gh6' size='340' side='right'caption='[[4gh6]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gh6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GH6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LUO:N-(4-METHOXYPHENYL)-N~2~-[1-(2-METHYLPHENYL)-4-OXO-4,5-DIHYDRO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-YL]-L-ALANINAMIDE'>LUO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gh6 OCA], [https://pdbe.org/4gh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gh6 RCSB], [https://www.ebi.ac.uk/pdbsum/4gh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gh6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>


===Crystal structure of the PDE9A catalytic domain in complex with inhibitor 28===
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[4gh6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GH6 OCA].
__TOC__
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hou, J.]]
[[Category: Large Structures]]
[[Category: Ke, H.]]
[[Category: Hou J]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Ke H]]
[[Category: Pde9a]]
Retrieved from "https://proteopedia.org/4gh6"