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[[Image:1exf.png|left|200px]]


{{STRUCTURE_1exf|  PDB=1exf  |  SCENE= }}
==EXFOLIATIVE TOXIN A==
 
<StructureSection load='1exf' size='340' side='right'caption='[[1exf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===EXFOLIATIVE TOXIN A===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1exf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EXF FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
[[1exf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] and [http://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXF OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1exf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exf OCA], [https://pdbe.org/1exf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1exf RCSB], [https://www.ebi.ac.uk/pdbsum/1exf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1exf ProSAT]</span></td></tr>
 
</table>
==Reference==
== Function ==
<ref group="xtra">PMID:009048539</ref><references group="xtra"/>
[https://www.uniprot.org/uniprot/ETA_STAAU ETA_STAAU] Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).<ref>PMID:2117445</ref> <ref>PMID:2384148</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1exf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1exf ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Unidentified]]
[[Category: Bohach GA]]
[[Category: Bohach, G A.]]
[[Category: Earhart CA]]
[[Category: Earhart, C A.]]
[[Category: Kim MH]]
[[Category: Kim, M H.]]
[[Category: Ohlendorf DH]]
[[Category: Ohlendorf, D H.]]
[[Category: Rago JV]]
[[Category: Rago, J V.]]
[[Category: Schlievert PM]]
[[Category: Schlievert, P M.]]
[[Category: Vath GM]]
[[Category: Vath, G M.]]
[[Category: Hydrolase]]
[[Category: Serine protease]]
[[Category: Superantigen]]
Retrieved from "https://proteopedia.org/1exf"