1ey1: Difference between revisions

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[[Image:1ey1.png|left|200px]]


{{STRUCTURE_1ey1| PDB=1ey1 | SCENE= }}
==SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB==
<StructureSection load='1ey1' size='340' side='right'caption='[[1ey1]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ey1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EY1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ey1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ey1 OCA], [https://pdbe.org/1ey1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ey1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ey1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ey1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NUSB_ECOLI NUSB_ECOLI] One of the proteins essential for the formation of the RNA polymerase antitermination complex in the presence of lambda phage N protein. However, it is involved in the transcription termination process at certain sites during normal bacterial growth. Binds to the BoxA RNA motif.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/1ey1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ey1 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have determined the solution structure of NusB, a transcription antitermination protein from Escherichia coli. The structure reveals a novel, all alpha-helical protein fold. NusB mutations that cause a loss of function (NusB5) or alter specificity for RNA targets (NusB101) are localized to surface residues and likely affect RNA-protein or protein-protein interactions. Residues that are highly conserved among homologs stabilize the protein core. The solution structure of E. coli NusB presented here resembles that of Mycobacterium tuberculosis NusB determined by X-ray diffraction, but differs substantially from a solution structure of E. coli NusB reported earlier.


===SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB===
The structure of the transcriptional antiterminator NusB from Escherichia coli.,Altieri AS, Mazzulla MJ, Horita DA, Coats RH, Wingfield PT, Das A, Court DL, Byrd RA Nat Struct Biol. 2000 Jun;7(6):470-4. PMID:10881193<ref>PMID:10881193</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
[[1ey1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EY1 OCA].
<div class="pdbe-citations 1ey1" style="background-color:#fffaf0;"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:010881193</ref><ref group="xtra">PMID:014636602</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Altieri, A S.]]
[[Category: Large Structures]]
[[Category: Coats, R H.]]
[[Category: Altieri AS]]
[[Category: Horita, D A.]]
[[Category: Byrd RA]]
[[Category: Mazzulla, M J.]]
[[Category: Coats RH]]
[[Category: Wingfield, P T.]]
[[Category: Horita DA]]
[[Category: Transcirption termination]]
[[Category: Mazzulla MJ]]
[[Category: Transcription]]
[[Category: Wingfield PT]]
Retrieved from "https://proteopedia.org/1ey1"