Tryptase: Difference between revisions

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~~{{STRUCTURE_2zeb| PDB~~=2zeb ~~| SIZE~~=~~400| SCENE~~= |right~~|CAPTION~~=Human tryptase β-2 tetramer complex with inhibitor, [[2zeb]] }}

== Function ==

'''Tryptase''' (TRP) is a serine protease found in mast cells<ref>PMID:15200544</ref>.

~~'''Tryptase''' (TRP) is a serine protease found in mast cells.~~ TRP is used as a marker for mast cell activation.

== Relevance ==

TRP is used as a marker for mast cell activation<ref>PMID:1607547</ref>. Inhibitors of TRP have therapeutic potential for treating allergic or inflammatory disorders such as asthma and inflammatory bowel diseases<ref>PMID:16640553</ref>.

~~{{TOC limit|limit=2}}~~

== Structural highlights ==

The biological assembly of Human tryptase is <scene name='46/465443/Cv/5'>homotetramer</scene> ([[2zeb]]). The <scene name='46/465443/Cv/6'>piperidine derivative TRP inhibitor interacts with both subunits of TRP</scene><ref>PMID:18272363</ref>. Water molecules are shown as red spheres.

</StructureSection>

== 3D Structures of tryptase ==

~~''Update July 2012''~~

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

{{#tree:id=OrganizedByTopic|openlevels=0|

~~[[1lto]] – hTRP-α1 - human ~~

*Tryptase

~~[[2f9o]] - hTRP-α1 (mutant)~~

~~===Tryptase complex with inhibitor===~~

**[[1lto]] – hTRP-α1 - human

**[[2f9o]] - hTRP-α1 (mutant)

**[[5wi6]] - hTRP-α/β1 (mutant)

~~[[1a0l]] – hTRP-β + APPA ~~

*Tryptase complex with inhibitor

~~[[2f9n]], [[2f9p]] - hTRP-α1 (mutant) + leupeptin ~~

~~[[2bm2]], [[2fww]] - hTRP-β2 + piperidine derivative ~~

~~[[4a6l]] - hTRP-α/β1 + piperidine derivative ~~

~~[[2fxr]] - hTRP-β2 + ketone~~ inhibitor~~ ~~

~~[[2fpz]] - hTRP-β2 + benzimidazole inhibitor ~~

~~[[2fs9]], [[2fs8]], [[2gdd]], [[2za5]], [[2zeb]], [[2zec]] - hTRP-β2 + inhibitor ~~

**[[1a0l]] – hTRP-β + APPA

**[[2f9n]], [[2f9p]] - hTRP-α1 (mutant) + leupeptin

**[[2bm2]], [[2fww]] - hTRP-β2 + piperidine derivative

**[[5f03]] - hTRP-β2 + oxazolidine derivative

**[[4a6l]], [[6p0p]] - hTRP-α/β1 + piperidine derivative

**[[4mpu]], [[4mpv]], [[4mpw]], [[4mpx]], [[4mqa]] - hTRP-α/β1 + drug

**[[6vvu]] - hTRP-α/1 + antibody

**[[6o1f]] - hTRP-α/β1 + trypsin inhibitor + antibody

**[[2fxr]] - hTRP-β2 + ketone inhibitor

**[[2fpz]] - hTRP-β2 + benzimidazole inhibitor

**[[2fs9]], [[2fs8]], [[2gdd]], [[2za5]], [[2zeb]], [[2zec]] - hTRP-β2 + inhibitor

**[[3v7t]] - hTRP-β2 + tropanylamide inhibitor

}}

== References ==

[[Category:Topic Page]]

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-{{STRUCTURE_2zeb|  PDB=2zeb  | SIZE=400| SCENE= |right|CAPTION=Human tryptase β-2 tetramer complex with inhibitor, [[2zeb]] }}
+<StructureSection load='2zeb' size='350' side='right' caption='Human tryptase β-2 tetramer complex with piperidine derivative inhibitor, [[2zeb]]' scene='46/465443/Cv/1' pspeed='8'>
+== Function ==
+'''Tryptase''' (TRP) is a serine protease found in mast cells<ref>PMID:15200544</ref>.
-'''Tryptase''' (TRP) is a serine protease found in mast cells.  TRP is used as a marker for mast cell activation.
+== Relevance ==
+TRP is used as a marker for mast cell activation<ref>PMID:1607547</ref>.  Inhibitors of TRP have therapeutic potential for treating allergic or inflammatory disorders such as asthma and inflammatory bowel diseases<ref>PMID:16640553</ref>.
-{{TOC limit|limit=2}}
+== Structural highlights ==
+The biological assembly of Human tryptase is <scene name='46/465443/Cv/5'>homotetramer</scene> ([[2zeb]]). The <scene name='46/465443/Cv/6'>piperidine derivative TRP inhibitor interacts with both subunits of TRP</scene><ref>PMID:18272363</ref>. Water molecules are shown as red spheres.
+</StructureSection>
 == 3D Structures of tryptase ==
-''Update July 2012''
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[1lto]] – hTRP-α1 - human<br />
+*Tryptase
-[[2f9o]] - hTRP-α1 (mutant)
-===Tryptase complex with inhibitor===
+**[[1lto]] – hTRP-α1 - human<br />
+**[[2f9o]] - hTRP-α1 (mutant)<br />
+**[[5wi6]] - hTRP-α/β1 (mutant)<br />
-[[1a0l]] – hTRP-β + APPA <br />
+*Tryptase complex with inhibitor
-[[2f9n]], [[2f9p]] - hTRP-α1 (mutant) + leupeptin<br />
-[[2bm2]], [[2fww]] - hTRP-β2 + piperidine derivative<br />
-[[4a6l]] - hTRP-α/β1 + piperidine derivative<br />
-[[2fxr]] - hTRP-β2 + ketone inhibitor<br />
-[[2fpz]] - hTRP-β2 + benzimidazole inhibitor<br />
-[[2fs9]], [[2fs8]], [[2gdd]], [[2za5]], [[2zeb]], [[2zec]] - hTRP-β2 + inhibitor<br />
+**[[1a0l]] – hTRP-β + APPA <br />
+**[[2f9n]], [[2f9p]] - hTRP-α1 (mutant) + leupeptin<br />
+**[[2bm2]], [[2fww]] - hTRP-β2 + piperidine derivative<br />
+**[[5f03]] - hTRP-β2 + oxazolidine derivative<br />
+**[[4a6l]], [[6p0p]] - hTRP-α/β1 + piperidine derivative<br />
+**[[4mpu]], [[4mpv]], [[4mpw]], [[4mpx]], [[4mqa]] - hTRP-α/β1 + drug<br />
+**[[6vvu]] - hTRP-α/1 + antibody<br />
+**[[6o1f]] - hTRP-α/β1 + trypsin inhibitor + antibody<br />
+**[[2fxr]] - hTRP-β2 + ketone inhibitor<br />
+**[[2fpz]] - hTRP-β2 + benzimidazole inhibitor<br />
+**[[2fs9]], [[2fs8]], [[2gdd]], [[2za5]], [[2zeb]], [[2zec]] - hTRP-β2 + inhibitor<br />
+**[[3v7t]] - hTRP-β2 + tropanylamide inhibitor<br />
+}}
+== References ==
+<references/>
     [[Category:Topic Page]]