4hz0: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4hz0 is ~~ON HOLD~~

==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.==

== Structural highlights ==

<table><tr><td colspan='2'>[[4hz0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZ0 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4HZ0 FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1AV:7-(1H-IMIDAZOL-1-YL)-2-(PYRIDIN-3-YL)[1,3]THIAZOLO[5,4-D]PYRIMIDIN-5-AMINE'>1AV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4hz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hz0 OCA], [https://pdbe.org/4hz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hz0 RCSB], [https://www.ebi.ac.uk/pdbsum/4hz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hz0 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PARE_ECOLI PARE_ECOLI] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:21300644</ref> <ref>PMID:15105144</ref> <ref>PMID:20921377</ref>

~~Authors~~: Bensen~~, D.C., Trzoss, M ,~~ Tari~~, L.W.~~

==See Also==

*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]

~~Description~~: ~~PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC ACTIVITY.~~

== References ==

__TOC__

</StructureSection>

[[Category: Escherichia coli K-12]]

[[Category: Large Structures]]

[[Category: Bensen DC]]

[[Category: Tari LW]]

[[Category: Trzoss M]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4hz0 is ON HOLD
+==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.==
+<StructureSection load='4hz0' size='340' side='right'caption='[[4hz0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4hz0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HZ0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1AV:7-(1H-IMIDAZOL-1-YL)-2-(PYRIDIN-3-YL)[1,3]THIAZOLO[5,4-D]PYRIMIDIN-5-AMINE'>1AV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hz0 OCA], [https://pdbe.org/4hz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hz0 RCSB], [https://www.ebi.ac.uk/pdbsum/4hz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hz0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PARE_ECOLI PARE_ECOLI] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:21300644</ref> <ref>PMID:15105144</ref> <ref>PMID:20921377</ref>
-Authors: Bensen, D.C., Trzoss, M , Tari, L.W.
+==See Also==
+*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
-Description: PYRROLOPYRIMIDINE INHIBITORS OF DNA GYRASE B AND TOPOISOMERASE IV, PART I: STRUCTURE GUIDED DISCOVERY AND OPTIMIZATION OF DUAL TARGETING AGENTS WITH POTENT, BROAD-SPECTRUM ENZYMATIC ACTIVITY.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Escherichia coli K-12]]
+[[Category: Large Structures]]
+[[Category: Bensen DC]]
+[[Category: Tari LW]]
+[[Category: Trzoss M]]