1fs5: Difference between revisions

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[[Image:1fs5.png|left|200px]]


{{STRUCTURE_1fs5| PDB=1fs5 | SCENE= }}
==A DISCOVERY OF THREE ALTERNATE CONFORMATIONS IN THE ACTIVE SITE OF GLUCOSAMINE-6-PHOSPHATE ISOMERASE==
<StructureSection load='1fs5' size='340' side='right'caption='[[1fs5]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1fs5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FS5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fs5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fs5 OCA], [https://pdbe.org/1fs5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fs5 RCSB], [https://www.ebi.ac.uk/pdbsum/1fs5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fs5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NAGB_ECOLI NAGB_ECOLI] Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.[HAMAP-Rule:MF_01241]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/1fs5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fs5 ConSurf].
<div style="clear:both"></div>


===A DISCOVERY OF THREE ALTERNATE CONFORMATIONS IN THE ACTIVE SITE OF GLUCOSAMINE-6-PHOSPHATE ISOMERASE===
==See Also==
 
*[[Deaminase 3D structures|Deaminase 3D structures]]
{{ABSTRACT_PUBMED_11752775}}
__TOC__
 
</StructureSection>
==About this Structure==
[[1fs5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FS5 OCA].
 
==Reference==
<ref group="xtra">PMID:011752775</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Glucosamine-6-phosphate deaminase]]
[[Category: Large Structures]]
[[Category: Horjales, E.]]
[[Category: Horjales E]]
[[Category: Morales-Arrieta, S.]]
[[Category: Morales-Arrieta S]]
[[Category: Rojas-Trejo, S P.]]
[[Category: Rojas-Trejo SP]]
[[Category: Rudino-Pinera, E.]]
[[Category: Rudino-Pinera E]]
[[Category: Aldose-ketose isomerase]]
[[Category: Allosteric enzyme]]
[[Category: Entropic effect]]
[[Category: Isomerase]]
[[Category: Multiple conformer]]
Retrieved from "https://proteopedia.org/1fs5"