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[[Image:1g0r.png|left|200px]]


{{STRUCTURE_1g0r| PDB=1g0r | SCENE= }}
==THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). THYMIDINE/GLUCOSE-1-PHOSPHATE COMPLEX.==
<StructureSection load='1g0r' size='340' side='right'caption='[[1g0r]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1g0r]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G0R FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G1P:ALPHA-D-GLUCOSE-1-PHOSPHATE'>G1P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g0r OCA], [https://pdbe.org/1g0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g0r RCSB], [https://www.ebi.ac.uk/pdbsum/1g0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g0r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9HU22_PSEAE Q9HU22_PSEAE] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity).[RuleBase:RU003706]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/1g0r_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g0r ConSurf].
<div style="clear:both"></div>


===THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). THYMIDINE/GLUCOSE-1-PHOSPHATE COMPLEX.===
==See Also==
 
*[[Glucose-1-phosphate thymidylyltransferase 3D structures|Glucose-1-phosphate thymidylyltransferase 3D structures]]
{{ABSTRACT_PUBMED_11118200}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[1g0r]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G0R OCA].
 
==Reference==
<ref group="xtra">PMID:011118200</ref><references group="xtra"/>
[[Category: Glucose-1-phosphate thymidylyltransferase]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Asuncion, M.]]
[[Category: Asuncion M]]
[[Category: Blankenfeldt, W.]]
[[Category: Blankenfeldt W]]
[[Category: Lam, J S.]]
[[Category: Lam JS]]
[[Category: Naismith, J H.]]
[[Category: Naismith JH]]
[[Category: Allostery]]
[[Category: L-rhamnose]]
[[Category: Nucleotidyltransferase]]
[[Category: Pyrophosphorylase]]
[[Category: Thymidylyltransferase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1g0r"