1gua: Difference between revisions

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[[Image:1gua.png|left|200px]]


{{STRUCTURE_1gua|  PDB=1gua  |  SCENE=  }}
==HUMAN RAP1A, RESIDUES 1-167, DOUBLE MUTANT (E30D,K31E) COMPLEXED WITH GPPNHP AND THE RAS-BINDING-DOMAIN OF HUMAN C-RAF1, RESIDUES 51-131==
 
<StructureSection load='1gua' size='340' side='right'caption='[[1gua]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===HUMAN RAP1A, RESIDUES 1-167, DOUBLE MUTANT (E30D,K31E) COMPLEXED WITH GPPNHP AND THE RAS-BINDING-DOMAIN OF HUMAN C-RAF1, RESIDUES 51-131===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1gua]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GUA FirstGlance]. <br>
{{ABSTRACT_PUBMED_8756332}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gua OCA], [https://pdbe.org/1gua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gua RCSB], [https://www.ebi.ac.uk/pdbsum/1gua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gua ProSAT]</span></td></tr>
[[1gua]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUA OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAP1A_HUMAN RAP1A_HUMAN] Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/1gua_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gua ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[C-Raf|C-Raf]]
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
*[[Molecular Playground/C-Raf|Molecular Playground/C-Raf]]
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:008756332</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Nassar, N.]]
[[Category: Large Structures]]
[[Category: Wittinghofer, A.]]
[[Category: Nassar N]]
[[Category: Oncogene protein/kinase/effector protein gtp-binding-protein]]
[[Category: Wittinghofer A]]
Retrieved from "https://proteopedia.org/1gua"