4i0a: Difference between revisions
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==structure of the mutant Catabolite gene activator protein V132A== | |||
<StructureSection load='4i0a' size='340' side='right'caption='[[4i0a]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4i0a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I0A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0a OCA], [https://pdbe.org/4i0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i0a RCSB], [https://www.ebi.ac.uk/pdbsum/4i0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i0a ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> | |||
==See Also== | |||
*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Burnell D]] | |||
[[Category: Cann MJ]] | |||
[[Category: McLeish TCB]] | |||
[[Category: Pohl E]] | |||
[[Category: Rodgers T]] | |||
[[Category: Townsend PD]] | |||
[[Category: Wilson MR]] | |||
Latest revision as of 11:48, 1 March 2024
structure of the mutant Catabolite gene activator protein V132A
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