4gp0: Difference between revisions
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==The crystal structure of human fascin 1 R149A K150A R151A mutant== | |||
<StructureSection load='4gp0' size='340' side='right'caption='[[4gp0]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4gp0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GP0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gp0 OCA], [https://pdbe.org/4gp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gp0 RCSB], [https://www.ebi.ac.uk/pdbsum/4gp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gp0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FSCN1_HUMAN FSCN1_HUMAN] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.<ref>PMID:9362073</ref> <ref>PMID:9571235</ref> <ref>PMID:20137952</ref> <ref>PMID:20393565</ref> | |||
== | ==See Also== | ||
*[[Fascin|Fascin]] | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Chen L]] | ||
[[Category: Diaz-Avalos | [[Category: Chen S]] | ||
[[Category: Huang | [[Category: Diaz-Avalos R]] | ||
[[Category: Huang | [[Category: Huang FK]] | ||
[[Category: Huang | [[Category: Huang J]] | ||
[[Category: Jakoncic | [[Category: Huang XY]] | ||
[[Category: Leo-Macias | [[Category: Jakoncic J]] | ||
[[Category: Yang | [[Category: Leo-Macias A]] | ||
[[Category: Zhang | [[Category: Yang SY]] | ||
[[Category: Zhang JJ]] | |||
Latest revision as of 15:52, 14 March 2024
The crystal structure of human fascin 1 R149A K150A R151A mutant
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