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[[Image:1ico.png|left|200px]]


{{STRUCTURE_1ico| PDB=1ico |  SCENE= }}
==SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX==
<StructureSection load='1ico' size='340' side='right'caption='[[1ico]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ico]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ICO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 42 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ico FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ico OCA], [https://pdbe.org/1ico PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ico RCSB], [https://www.ebi.ac.uk/pdbsum/1ico PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ico ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.


===SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX===
Design of a discretely folded mini-protein motif with predominantly beta-structure.,Ottesen JJ, Imperiali B Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623<ref>PMID:11373623</ref>


{{ABSTRACT_PUBMED_11373623}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 1ico" style="background-color:#fffaf0;"></div>
[[1ico]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:011373623</ref><references group="xtra"/>
</StructureSection>
[[Category: Imperiali, B.]]
[[Category: Large Structures]]
[[Category: Ottesen, J J.]]
[[Category: Imperiali B]]
[[Category: De novo protein]]
[[Category: Ottesen JJ]]
[[Category: De novo protein design three-stranded beta-sheet mini-protein motif th motif]]
Retrieved from "https://proteopedia.org/1ico"