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[[Image:1ic2.png|left|200px]]


{{STRUCTURE_1ic2|  PDB=1ic2  |  SCENE=  }}
==DECIPHERING THE DESIGN OF THE TROPOMYOSIN MOLECULE==
 
<StructureSection load='1ic2' size='340' side='right'caption='[[1ic2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===DECIPHERING THE DESIGN OF THE TROPOMYOSIN MOLECULE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ic2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IC2 FirstGlance]. <br>
{{ABSTRACT_PUBMED_11438684}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ic2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ic2 OCA], [https://pdbe.org/1ic2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ic2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ic2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ic2 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1ic2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC2 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/TPM1_CHICK TPM1_CHICK] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/1ic2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ic2 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Tropomyosin|Tropomyosin]]
*[[Tropomyosin 3D structures|Tropomyosin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:011438684</ref><references group="xtra"/>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Brown, J H.]]
[[Category: Large Structures]]
[[Category: Cohen, C.]]
[[Category: Brown JH]]
[[Category: Dominguez, R.]]
[[Category: Cohen C]]
[[Category: Greenfield, N J.]]
[[Category: Dominguez R]]
[[Category: Hitchcock-DeGregori, S E.]]
[[Category: Greenfield NJ]]
[[Category: Jun, G.]]
[[Category: Hitchcock-DeGregori SE]]
[[Category: Kim, K H.]]
[[Category: Jun G]]
[[Category: Volkmann, N.]]
[[Category: Kim K-H]]
[[Category: Alanine]]
[[Category: Volkmann N]]
[[Category: Alpha-helical coiled coil]]
[[Category: Axial stagger]]
[[Category: Bend]]
[[Category: Contractile protein]]
[[Category: Symmetry]]
Retrieved from "https://proteopedia.org/1ic2"