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[[Image:1im4.png|left|200px]]


{{STRUCTURE_1im4|  PDB=1im4  |  SCENE=  }}
==Crystal Structure of a DinB Homolog (DBH) Lesion Bypass DNA Polymerase Catalytic Fragment from Sulfolobus solfataricus==
 
<StructureSection load='1im4' size='340' side='right'caption='[[1im4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal Structure of a DinB Homolog (DBH) Lesion Bypass DNA Polymerase Catalytic Fragment from Sulfolobus solfataricus===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1im4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IM4 FirstGlance]. <br>
{{ABSTRACT_PUBMED_11545744}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1im4 OCA], [https://pdbe.org/1im4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1im4 RCSB], [https://www.ebi.ac.uk/pdbsum/1im4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1im4 ProSAT]</span></td></tr>
[[1im4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IM4 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/DPO4_SACSO DPO4_SACSO] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.
<ref group="xtra">PMID:011545744</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: DNA-directed DNA polymerase]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Sulfolobus solfataricus]]
Check<jmol>
[[Category: Pata, J D.]]
  <jmolCheckbox>
[[Category: Steitz, T A.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/1im4_consurf.spt"</scriptWhenChecked>
[[Category: Zhou, B L.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Dna polymerase palm]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Fidelity]]
  </jmolCheckbox>
[[Category: Finger]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1im4 ConSurf].
[[Category: Helix-hairpin-helix]]
<div style="clear:both"></div>
[[Category: Processivity]]
__TOC__
[[Category: Thumb]]
</StructureSection>
[[Category: Transferase]]
[[Category: Large Structures]]
[[Category: Saccharolobus solfataricus]]
[[Category: Pata JD]]
[[Category: Steitz TA]]
[[Category: Zhou BL]]
Retrieved from "https://proteopedia.org/1im4"