4h6v: Difference between revisions

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[[Image:4h6v.png|left|200px]]


{{STRUCTURE_4h6v| PDB=4h6v | SCENE= }}
==Structure of Patellamide maturation protease PatA==
<StructureSection load='4h6v' size='340' side='right'caption='[[4h6v]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4h6v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Prochloron_didemni Prochloron didemni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H6V FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h6v OCA], [https://pdbe.org/4h6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h6v RCSB], [https://www.ebi.ac.uk/pdbsum/4h6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h6v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q52QI9_PRODI Q52QI9_PRODI]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cyanobactins, a class of ribosomally encoded macrocylic natural products, are biosynthesized through the proteolytic processing and subsequent N-C macrocylization of ribosomal peptide precursors. Macrocylization occurs through a two-step process in which the first protease (PatA) removes the amino terminal flanking sequence from the precursor to yield a free N terminus of the precursor peptide, and the second protease (PatG) removes the C-terminal flanking sequence and then catalyzes the transamidation reaction to yield an N-C cyclized product. Here, we present the crystal structures of the protease domains of PatA and PatG from the patellamide cluster and of PagA from the prenylagaramide cluster. A comparative structural and biochemical analysis of the transamidating PatG protease reveals the presence of a unique structural element distinct from canonical subtilisin proteases, which may facilitate the N-C macrocylization of the peptide substrate.


===Structure of Patellamide maturation protease PatA===
Structures of cyanobactin maturation enzymes define a family of transamidating proteases.,Agarwal V, Pierce E, McIntosh J, Schmidt EW, Nair SK Chem Biol. 2012 Nov 21;19(11):1411-22. doi: 10.1016/j.chembiol.2012.09.012. PMID:23177196<ref>PMID:23177196</ref>


{{ABSTRACT_PUBMED_23177196}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 4h6v" style="background-color:#fffaf0;"></div>
[[4h6v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Prochloron_didemni Prochloron didemni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H6V OCA].
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Prochloron didemni]]
[[Category: Prochloron didemni]]
[[Category: Agarwal, V.]]
[[Category: Agarwal V]]
[[Category: Nair, S K.]]
[[Category: Nair SK]]
[[Category: Hydrolase]]
[[Category: Protease]]
Retrieved from "https://proteopedia.org/4h6v"