4g3u: Difference between revisions

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[[Image:4g3u.jpg|left|200px]]


{{STRUCTURE_4g3u|  PDB=4g3u  |  SCENE=  }}
==Mycobacterium smegmatis DprE1 - monoclinic crystal form==
 
<StructureSection load='4g3u' size='340' side='right'caption='[[4g3u]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
===Mycobacterium smegmatis DprE1 - monoclinic crystal form===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4g3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3U FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.689&#8491;</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3u OCA], [https://pdbe.org/4g3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3u RCSB], [https://www.ebi.ac.uk/pdbsum/4g3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3u ProSAT]</span></td></tr>
[[4g3u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3U OCA].  
</table>
[[Category: Mycobacterium smegmatis]]
== Function ==
[[Category: Jogl, G.]]
[https://www.uniprot.org/uniprot/DPRE1_MYCS2 DPRE1_MYCS2] Component of the DprE1-DprE2 complex that catalyzes the 2-step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans (PubMed:22188377). DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX) (PubMed:22188377). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate channel' at the interface of DprE1-DprE2 complex (By similarity). Can also use farnesyl-phosphoryl-beta-D-ribofuranose (FPR) as substrate in vitro (PubMed:22188377, PubMed:22956199). Appears to be essential for the growth of M.smegmatis (PubMed:21346818).[UniProtKB:P9WJF1]<ref>PMID:21346818</ref> <ref>PMID:22188377</ref> <ref>PMID:22956199</ref>
[[Category: Li, H.]]
== References ==
[[Category: Oxidoreductase]]
<references/>
[[Category: Vao superfamily]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycolicibacterium smegmatis]]
[[Category: Jogl G]]
[[Category: Li H]]
Retrieved from "https://proteopedia.org/4g3u"