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[[Image:1jmk.png|left|200px]]


{{STRUCTURE_1jmk|  PDB=1jmk  |  SCENE=  }}
==Structural Basis for the Cyclization of the Lipopeptide Antibiotic Surfactin by the Thioesterase Domain SrfTE==
 
<StructureSection load='1jmk' size='340' side='right'caption='[[1jmk]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
===Structural Basis for the Cyclization of the Lipopeptide Antibiotic Surfactin by the Thioesterase Domain SrfTE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1jmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JMK FirstGlance]. <br>
{{ABSTRACT_PUBMED_12005429}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jmk OCA], [https://pdbe.org/1jmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jmk RCSB], [https://www.ebi.ac.uk/pdbsum/1jmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jmk ProSAT]</span></td></tr>
[[1jmk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMK OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/SRFAC_BACSU SRFAC_BACSU] Probably activates a leucine.
<ref group="xtra">PMID:012005429</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/1jmk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jmk ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Bruner, S D.]]
[[Category: Large Structures]]
[[Category: Kohli, R M.]]
[[Category: Bruner SD]]
[[Category: Marahiel, M A.]]
[[Category: Kohli RM]]
[[Category: Schwarzer, D.]]
[[Category: Marahiel MA]]
[[Category: Stubbs, M T.]]
[[Category: Schwarzer D]]
[[Category: Walsh, C T.]]
[[Category: Stubbs MT]]
[[Category: Weber, T.]]
[[Category: Walsh CT]]
[[Category: Alpha-beta hydrolase]]
[[Category: Weber T]]
[[Category: Cyclic peptide]]
[[Category: Hydrolase]]
[[Category: Non-ribosomal peptide synthesis]]
[[Category: Thioesterase]]
Retrieved from "https://proteopedia.org/1jmk"