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[[Image:1jfa.png|left|200px]]


{{STRUCTURE_1jfa| PDB=1jfa | SCENE= }}
==Trichodiene Synthase from Fusarium Sporotrichioides==
<StructureSection load='1jfa' size='340' side='right'caption='[[1jfa]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1jfa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_sporotrichioides Fusarium sporotrichioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JFA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfa OCA], [https://pdbe.org/1jfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jfa RCSB], [https://www.ebi.ac.uk/pdbsum/1jfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRI5_FUSSP TRI5_FUSSP] TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/1jfa_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jfa ConSurf].
<div style="clear:both"></div>


===Trichodiene Synthase from Fusarium Sporotrichioides===
==See Also==
 
*[[Trichodiene synthase|Trichodiene synthase]]
{{ABSTRACT_PUBMED_11698643}}
__TOC__
 
</StructureSection>
==About this Structure==
[[1jfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_sporotrichioides Fusarium sporotrichioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFA OCA].
 
==Reference==
<ref group="xtra">PMID:011698643</ref><references group="xtra"/>
[[Category: Fusarium sporotrichioides]]
[[Category: Fusarium sporotrichioides]]
[[Category: Trichodiene synthase]]
[[Category: Large Structures]]
[[Category: Cane, D E.]]
[[Category: Cane DE]]
[[Category: Christianson, D W.]]
[[Category: Christianson DW]]
[[Category: Rynkiewicz, M J.]]
[[Category: Rynkiewicz MJ]]
[[Category: Lyase]]
[[Category: Terpenoid synthase fold]]
Retrieved from "https://proteopedia.org/1jfa"