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[[Image:1jwx.png|left|200px]]


{{STRUCTURE_1jwx| PDB=1jwx | SCENE= }}
==Chalcone Synthase--F215S mutant==
<StructureSection load='1jwx' size='340' side='right'caption='[[1jwx]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1jwx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JWX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jwx OCA], [https://pdbe.org/1jwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jwx RCSB], [https://www.ebi.ac.uk/pdbsum/1jwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jwx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CHS2_MEDSA CHS2_MEDSA] The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.<ref>PMID:10653632</ref> <ref>PMID:11732902</ref> <ref>PMID:11959984</ref> <ref>PMID:15380179</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/1jwx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jwx ConSurf].
<div style="clear:both"></div>


===Chalcone Synthase--F215S mutant===
==See Also==
 
*[[Chalcone synthase|Chalcone synthase]]
{{ABSTRACT_PUBMED_11959984}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1jwx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWX OCA].
</StructureSection>
 
[[Category: Large Structures]]
==Reference==
<ref group="xtra">PMID:011959984</ref><references group="xtra"/>
[[Category: Medicago sativa]]
[[Category: Medicago sativa]]
[[Category: Naringenin-chalcone synthase]]
[[Category: Bowman ME]]
[[Category: Bowman, M E.]]
[[Category: Jez JM]]
[[Category: Jez, J M.]]
[[Category: Noel JP]]
[[Category: Noel, J P.]]
[[Category: Altered substrate specificity]]
[[Category: Ketoacyl synthase]]
[[Category: Polyketide synthase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1jwx"