1k0e: Difference between revisions

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[[Image:1k0e.png|left|200px]]


{{STRUCTURE_1k0e|  PDB=1k0e  |  SCENE=  }}
==THE CRYSTAL STRUCTURE OF AMINODEOXYCHORISMATE SYNTHASE FROM FORMATE GROWN CRYSTALS==
 
<StructureSection load='1k0e' size='340' side='right'caption='[[1k0e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===THE CRYSTAL STRUCTURE OF AMINODEOXYCHORISMATE SYNTHASE FROM FORMATE GROWN CRYSTALS===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1k0e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K0E FirstGlance]. <br>
{{ABSTRACT_PUBMED_11841211}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0e OCA], [https://pdbe.org/1k0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k0e RCSB], [https://www.ebi.ac.uk/pdbsum/1k0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k0e ProSAT]</span></td></tr>
[[1k0e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0E OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/PABB_ECOLI PABB_ECOLI] Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabB, in the absence of PabA, can catalyze the formation of ADC in the presence of exogenous ammonia.<ref>PMID:4914080</ref> <ref>PMID:2251281</ref> <ref>PMID:16605270</ref>  
<ref group="xtra">PMID:011841211</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k0e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k0e ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Eisenstein, E.]]
[[Category: Large Structures]]
[[Category: Howard, A J.]]
[[Category: Eisenstein E]]
[[Category: Jensen, P Y.]]
[[Category: Howard AJ]]
[[Category: Ladner, J E.]]
[[Category: Jensen PY]]
[[Category: Pachikara, A S.]]
[[Category: Ladner JE]]
[[Category: Parsons, J F.]]
[[Category: Pachikara AS]]
[[Category: Aminodeoxychorismate synthase]]
[[Category: Parsons JF]]
[[Category: Chorismate]]
[[Category: Glutamine]]
[[Category: Lyase]]
[[Category: P-aminobenzoate synthase]]
[[Category: Paba synthase]]
[[Category: Tryptophan]]
Retrieved from "https://proteopedia.org/1k0e"